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Accelerate your Impurity / Degradation / Proteomics / Metabolite data mining with MsXelerator®

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Modern LC/MS experiments confront you with a wealth of data. Processing the data requires a substantial part of your time. MsXelerator® software suite empowers you to save valuable time analysing complex LC/MS data coming from a number of application areas.

MsXelerator is an extremely fast and comprehensive software suite for processing of chromatographic MS datasets. It is your choice for data processing in application areas such as: 

  • Impurity and Degradation Profiling
  • Metabolite Profiling
  • Differential Analysis
  • Metabonomics
  • Proteomics (Quantitative) and
  • Biomarker Discovery

MsXelerator is comprised of four modular packages, each of which contain of a number of unique algorithms unparalleled in speed, sensitivity and ease of use. Importing can be done directly from Xcalibur, Masslynx, NetCDF, mzXML or ASCII. Many problems encountered in the above areas can be solved using MsXelerator.

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Learn more about MsMetrix and read what users say about MsMetrix/MsXelerator

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What MSMetrix user say:


‘We successfully used the Reference Peak Warping (RPW) function of the MsXelerator software to align profiles of rat-urinary metabolites obtained by capillary electrophoresis–mass spectrometry. The excellent alignment allowed reliable principal component analysis revealing significant differences between antibiotic-treated and non-treated rats.’

Miranda de Kok, PhD, Biomedical Analysis, Dept. of Pharmaceutical Sciences, Faculty of Science University Utrecht, the Netherlands

‘We really enjoy working with MsMetrix to implement MsXelerator software according to our needs.  MsXelerator software, especially the part of the IPeaks module is a very powerful tool to process our routine reactive metabolite trapping data.’

Chenghong Zhang, Genentech (A Member of Roche), San Francisco, USA

 ‘MsXelerator enabled us to select peptides from very complex mixtures by recognition of their specifically induced isotope pattern. Manual inspection of thousands of spectra has been replaced by an hour of analysis time using MsXelerator.’

Dr. P.A. van Veelen, LUMC, Head Mass Spectrometry Group, Leiden, the Netherlands

 ‘At Evolva SA, we have been using MsXelerator with great success for more than 4 years. Finding unknown molecules in complex sample matrix requires challenging and extensive LC/MS data mining, without mentioning the time needed to review high throughput screening data. MsXelerator software and particularly the module MPeaks does a great job in deconvoluting and comparing MS chromatograms in order to find the small differences which are relevant for our applications. Moreover, the clever interactivity between MPeaks and MS-compare help us accelerating our analysis thanks to the multiple filters and statistical tools, all with great confidence. Beyond all doubt, MsXelerator is a powerful all-in-one software platform to process LC/MS data, removing the hassle of buying several expensive add-ons from the instrument vendors.

I also particularly enjoy the collaboration, expertise and quick responsiveness regarding customization to our special requests! ’

Christophe Folly, Research Scientist, Evolva SA, Switzerland

‘MsXelerator is a real time-saver when processing our discovery and (pre)clinical Met-ID experiments at MSD (Schering-Plough, Organon).’

  • One workflow in a multi vendor ms lab.
  • Searches for artificial isotope patterns at low level that worked (labeled compounds).
  • Customization.

Peter Jacobs, Head ADME Analysis, Schering-Plough

‘MsXelerator is an essential tool nowadays in processing our proteomics datasets. It provides sensitive algorithms to search for mass spectral doublets, either targeting absolute mass differences (in the context of e.g. SILAC-based proteomics experiments or chemical modifications of amino acids) or relative mass differences. This latter feature is unique in its kind, as it allocates14N/15N-isotopically labeled peptides characterized by a relative mass difference of 1.2% of the m/z-value of the peptide and user-specified peak intensity ratios. For our Immuno Proteomics research we often apply 14N/15N-metabolic labeling protocols to target MHC-presented epitopes. MsXelerator is exceptional in allocating these typical mass spectral doublets, based on relative mass differences, charge states and intensity ratios. All data processing is performed on the raw MS data, without any prior data conversion. 

MsXelerator also supports high resolution MS data (e.g. Orbitrap datasets) that significantly reduces the false positive hits and speeds up the automated processing of our complex and large data sets. The flexibility of the user interface, allows us to set and define many search parameters, depending on the design of the experiment. 

MsXelerator also features a good built-in browser to view the raw data (chromatograms, extracted ion chromatograms, mass spectra) without witching back and forth to the MS-vendor originating data system. It is without any doubt that this application has boosted our Immuno Proteomics research. Moreover, the good hands-on training and the direct contact with the software developers of MsXelerator allows us to have user-defined modules integrated in the basic version of the application. ’

Hugo D. Meiring, PhD, Scientist Biomolecular Mass Spectrometry
Unit Vaccinology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment.